Biomaterials as Stem Cell Niche by Sarah E. Stabenfeldt, Ashley Carson Brown (auth.),
By Sarah E. Stabenfeldt, Ashley Carson Brown (auth.), Krishnendu Roy (eds.)
Recent advancements in stem telephone biology have opened new instructions in phone remedy. This e-book offers the cutting-edge advancements in utilizing biomaterials as man made niches for engineering stem cells, either for the aim of higher realizing their biology lower than 3D biomimetic stipulations in addition to for constructing new concepts for effective long-term upkeep and directed differentiation of stem cells into a variety of healing lineages. Animal and human stem cells of either embryonic and grownup starting place are mentioned with functions starting from nerve regeneration, orthopedics, cardiovascular remedy, blood phone new release and melanoma treatment. either artificial and typical biomaterials are reviewed with emphasis on how material-stem cellphone interactions direct particular signaling pathways and finally modulate the mobilephone destiny. This booklet is efficacious for biomaterial scientists, tissue engineers, clinicians in addition to stem mobilephone biologists considering simple learn and functions of grownup and embryonic stem cells.
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Additional info for Biomaterials as Stem Cell Niche
At the single cell level, adhesion of cell to a material with specific stiffness triggers signaling transduction cascades allowing translation of extracellular mechanical cues into intracellular events . Dynamic interactions between cell and matrix control several cell behaviors such as spreading, migration and cell shape through binding with integrins, the chief mechanotransducers for cells . For example, cell geometry (spreading) is a result of pre-stress between ECM and cellular microtubules .
Treatment of carboxyl modified surfaces with b3 blocking antibody promoted mineralization on this surface; additionally treatment of amine modified surfaces with the same antibody led to an increase in mineralization. It is important to note that amine modified surfaces were expected to show greater b3 affinity than hydroxyl modified surfaces. These observations led the authors to suggest that binding of integrin a5b1 promotes osteogenic differentiation while avb3 suppresses it. Moursi et al.  reported that activity of integrin a5b1 is essential for triggering of upregulation of factors representing osteoblast activity.
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