Background Lesions in Laboratory Animals. A Color Atlas by Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

Veterinary Medicine

By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

Background Lesions in Laboratory Animals might be a useful reduction to pathologists wanting to acknowledge history and incidental lesions whereas analyzing slides taken from laboratory animals in acute and persistent toxicity stories, or whereas analyzing unique species in a diagnostic laboratory. It provides transparent descriptions and illustrations of nearly all of heritage lesions prone to be encountered. a number of the lesions lined are strange and will be wrong for treatment-related findings in preclinical toxicity studies.

The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all of the laboratory animal species lined and who've released broadly in those areas.

  • over six hundred high-definition, best colour pictures of heritage lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
  • a separate bankruptcy on lesions within the reproductive platforms of all laboratory animals written through Dr Dianne Creasy, an international specialist on testicular lesions in laboratory animals
  • a bankruptcy on universal artifacts that could be saw in histological glass slides
  • extensive references to every lesion described
  • aging lesions encountered in all laboratory animal species, relatively in rats in mice that are used for carcinogenicity studies

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Extra info for Background Lesions in Laboratory Animals. A Color Atlas

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J. Natl. Cancer Inst. 43, 749–762. , 1980. Effects of aging on the structural and permeability characteristics of cerebrovasculature in normotensive and hypertensive strains of rats. Acta. Neuropathol. 51, 1–13. , 1968. The peri-insular acini of the pancreas of the rat. Z. Zellforsch Mikrosk Anat. 86, 163–170. , 1990. Bones, joints and synovia. , et al. ), Pathology of the Fischer rat. Academic Press, San Diego, pp. 209–225. , 2011. Pneumocystis carinii infection causes lung lesions historically attributed to rat respiratory virus.

31–41. , 1996. Non-proliferative lesions of soft tissues and skeletal muscle in rats. In: MST-1 guides for toxicologic pathology. STP/ARP/AFIP, Washington DC. , 1991. Age-related accumulation of lysosomes and other cytological features in active thyroid follicles of the CBA mouse. Cell Tissue Res. 65, 275–285. , 1983. The aging male rat: structure and function of the kidney. Am. J. Anat. 67, 1–13. , 2007. Pathology of laboratory rodents and rabbits, third ed. Iowa State University Press, IA, p.

133). Cellular pleomorphism is a normal background change in the lacrimal gland. In addition, one can often see areas of Harderianization in the lacrimal gland (Fig. 134) and this is an example of sexual dimorphism of the extraorbital lacrimal gland in the rat (Ferrara et al 2004). Acinar atrophy and inflammation may be noted in the lacrimal gland (Fig. 135). Acinar hypertrophy may also be present in the lacrimal gland (Fig. 136). 133 Squamous hyperplasia of the Harderian gland in the rat. ×400.

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