Amine Oxidases: Function and Dysfunction: Proceedings of the by Dr. W. Weyler (auth.), Prof. Dr. K. F. Tipton, Prof. Dr. M.


By Dr. W. Weyler (auth.), Prof. Dr. K. F. Tipton, Prof. Dr. M. B. H. Youdim, Dr. C. J. Barwell, Prof. Dr. B. A. Callingham, Dr. G. A. Lyles (eds.)

Monoamine oxidase performs an immense position within the pathogenesis of neuropsychiatric problems together with depressive disease, Parkinson´s sickness and Alzheimer´s affliction. the hot new release of selective monoamine oxidase inhibitors, with out significant negative effects, has came upon a popular position within the therapy of those illnesses. a few of these medicines could have neuroprotective task with clients for treating revolutionary neurodegenerative ailments. the amount offers a suite of study papers on monoamine oxidase and its inhibitors. the subject is taken care of from the viewpoint of chemistry, biochemistry, pharmacology, body structure, neurology and psychiatry. The e-book serves as a short and entire reference resource for acquiring the freshest information.

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Extra info for Amine Oxidases: Function and Dysfunction: Proceedings of the 5th International Amine Oxidase Workshop, Galway, Ireland, August 22–25, 1992

Sample text

37 10 <1 ~ v v I ... 21 0 R bz Legend: D - Drall Hp- Hinp6 P - Pvull Ps - Pstl R - Rsal S-Smal • -CRE v _ CACCC element .... 36 I I Fig. 2. Restriction map of the MAO A promoter region and promoter activity measurements. At the top is the restriction enzyme map, where only restriction enzyme sites used for subcloning for promoter activity measurement are marked. The open box on the top line represents untranslated region and the closed box for the coding sequence of MAO exon 1. The potential transcription factor binding sites are numbered as in Table 1.

C c 20 ;! o L -_ _ _ _~------~----~------~ -12 -10 -8 -6 -4 log M clorgyline Fig. 1. In vitro effect of clorgyline upon tyramine de aminating activity of rat (0) and guinea pig (e) liver mitochondria. 4 and 37°C then remaining activity assayed with S mM tyramine Guinea pig monoamine oxidase 43 Table 1. 4 and 37°C with 5 mM benzylamine and tyramine. * The percentage of monoamine oxidase B in each preparation was determined from the plateau obtained by titration with clorgyline and assaying remaining activity with 5 mM tyramine, see Fig.

When azide was included activity became detectable and was apparently optimal at concentrations between 2 mM and 10 mM in the assay. Benzylamine deamination, measured as hydrogen peroxide production in the presence of 5 mM azide, was approximately one half that measured, as benzaldehyde production in the absence of azide. A similar relationship was found when enzyme activity was measured as benzaldehyde production, both in the absence and presence of 5 mM azide. The apparent inhibitory effect of azide was investigated using the assay based upon benzaldehyde production.

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